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High intensity focused ultrasound6/1/2023 While ultrasound (US) is often used in diagnostic equipment, it also has therapeutic applications in hyperthermia, HIFU, and histotripsy. Lastly, we summarize systematic reviews and meta-analyses on HIFU for PC and highlight new developments in the field. Further, we examine HIFU for PC in general and contrast the outcomes of HIFU in Japan and worldwide. In this review, we discuss the principles of HIFU as well as the equipment, mechanisms of its effects, and indications of HIFU. Moreover, the results of clinical trials with a large number of patients and their long-term outcomes have been published, and expectations for the clinical application of HIFU have accelerated. ![]() In recent years, high-intensity focused ultrasound (HIFU)-a minimally invasive treatment that does not involve radiation exposure, needles, or anesthesia-has garnered attention. Thus, novel treatments for PC with a poor prognosis are needed. Moreover, chemotherapy and chemo-radiotherapy are the standard of care for un-resectable PC, but their outcomes are not satisfactory, with a median survival time (MST) of only 7 months. Furthermore, the severe pain caused by advanced PC is extremely difficult to treat and may greatly affect the patient's quality of life (QOL). Despite the numerous methods for early diagnosis, 60–70% of all PCs are un-resectable. Pancreatic cancer (PC) has an increasing incidence and a 5-year overall survival rate of approximately 7%, one of the poorest prognoses among solid cancers. In future, HIFU could be utilized as a minimally invasive treatment strategy for PC patients with a poor prognosis. Although HIFU for PC has several limitations and further study is needed, this technique can be safely performed on un-resectable advanced PC. ![]() HIFU therapy for un-resectable PC is useful for its anti-tumor effect and pain relief, and is expected to prolong survival time and improve quality of life. Here, we discuss the usefulness of HIFU treatment for un-resectable advanced PC using the results of previous research, meta-analyses, and systematic reviews on its efficacy and safety. Although HIFU is a minimally invasive treatment and is expected to be useful, it is not yet generally known. In this therapy, only the focal area is heated to 80–100 ✬, which causes coagulative necrosis of the tissue, with hardly any impact on the tissue outside the focal area. High-intensity focused ultrasound (HIFU) is a novel therapy for ablating tissue from the outside of the body by focusing ultrasonic waves from multiple sources on the tumor. Satisfactory outcomes are not achieved with current therapies thus, novel treatments are urgently needed. Pancreatic cancer (PC) has one of the poorest prognoses among solid cancers, and its incidence has increased recently.
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